FAQs
What's the Difference?

Alka-Seltzer Plus®

Breaks up your worst
cold symptoms.

 

Alka-Seltzer®

Fast relief of acid
indigestion and pain.


Our FAQ will tell you just about everything you ever needed or wanted to
know about Alka-Seltzer Plus®. If your questions are not answered here or
elsewhere on this web site, please contact us.



 

Where can I find the dosage directions on the Alka-Seltzer Plus® Day & Night?

Liquid-Gels: On the lower edge of the back carton, you will see two down arrows. The back carton flap is designed to lift up and away from the box to provide the remaining information needed. This is where the dosage directions can be found. Please note that the information in blue (on the left) pertains to our Day Cold formula while information in green (on the right) pertains to the Night Cold formula. To view the directions on-line, please visit our product page.

Effervescents: The carton has a peel back label as indicated by the yellow tab noted "Lift Here" in the lower right corner of the back label. Once lifted, the remaining information visible. This is where the dosage directions can be found. Please note that the information in blue pertains to our Day Cold formula while the information in green pertains to the Night Cold formula. To view the directions on-line, please visit our product page.

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Does Alka-Seltzer Plus® contain Phenylpropanolamine Bitartrate (PPA)?

At this time, all of our products contain the nasal decongestant Phenylephrine Hydrochloride. We are no longer manufacturing Alka-Seltzer Plus products with Phenylpropanolamine (PPA). This ingredient was removed from Alka-Seltzer Plus® formulations in 2000.

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Which Alka-Seltzer Plus® formulas contain aspirin?

Alka-Seltzer Plus® Flu effervescent is the only product that contains aspirin. This formula contains 500mg of aspirin plus an antihistamine and a cough suppressant

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What is the purpose of the different ingredients in Alka-Seltzer Plus®?

The following provides an easy reference regarding the types of ingredients used in Alka-Seltzer Plus® and their purpose.

Drug Purpose
Acetaminophen Pain Reliever
Aspirin Pain Reliever
Chlorpheniramine Maleate Antihistamine
Phenylephrine Hydrochloride Nasal decongestant
Dextromethorphan Hydrobromide Cough Suppressant
Doxylamine Succinate Antihistamine
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Do the Alka-Seltzer Plus® effervescent tablets, Liquid-Gels and Liquids contain the same ingredients?

  Pain Reliever/Fever Reducer Antihistamine Cough Suppressant Nasal Decongestant
  Acetaminophen Aspirin Chlorpheniramine Maleate Doxylamine Succinate Dextromethorphan Hydrobromide Phenylephrine Hydrochloride
Effervescent Tablets
Alka-Seltzer Plus Cold Sparkling Original Effervescent
250mg
 
2mg
   
5mg
Alka-Seltzer Plus Classic/Regular Seltzer Effervescent
250mg
 
2mg
   
5mg
Alka-Seltzer Plus Cold Orange Zest Effervescent
250mg
 
2mg
   
5mg
Alka-Seltzer Plus Cold Cherry Burst Effervescent
250mg
 
2mg
   
5mg
Alka-Seltzer Plus Night Time Effervescent
250mg
   
6.25mg
10mg
5mg
Alka-Seltzer Plus Cold & Sinus Effervescent
250mg
 
Non-Drowsy Formula
   
5mg
Alka-Seltzer Plus Cold & Cough Effervescent
250mg
 
2mg
 
10mg
5mg
Alka-Seltzer Plus Flu Effervescent  
500mg
2mg
 
15mg
5mg
Alka-Seltzer Plus Day & Night Effervescent            
Day:
250mg
 
Non-Drowsy Formula
 
10mg
5mg
Night:
250mg
   
6.25mg
10mg
5mg
  Pain Reliever/Fever Reducer Antihistamine Cough Suppressant Nasal Decongestant
  Acetaminophen Aspirin Chlorpheniramine Maleate Doxylamine Succinate Dextromethorphan Hydrobromide Phenylephrine Hydrochloride
Liquid-Gels
Alka-Seltzer Plus Day Cold Liquid-gels
325mg
 
Non-Drowsy Formula
 
10mg
5mg
Alka-Seltzer Plus Cough and Cold Liquid-gel
325mg
     
10mg
5mg
Alka-Seltzer Plus Night Cold Liquid-gel
325mg
   
6.25mg
15mg
 
Alka-Seltzer Plus Day & Night Liquid-gels            
Day:
325mg
 
Non-Drowsy Formula
 
10mg
5mg
Night:
325mg
   
6.25mg
15mg
 
  Pain Reliever/Fever Reducer Antihistamine Cough Suppressant Nasal Decongestant
  Acetaminophen Aspirin Chlorpheniramine Maleate Doxylamine Succinate Dextromethorphan Hydrobromide Phenylephrine Hydrochloride
Liquids
Alka-Seltzer Plus Day Cold Liquid
162.5mg
 
Non-Drowsy Formula
 
5mg
2.5mg
Alka-Seltzer Plus Cold & Cough Liquid
162.5mg
 
1mg
 
5mg
2.5mg
Alka-Seltzer Plus Night Cold Liquid
162.5mg
   
3.125mg
5mg
2.5mg
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Are Alka-Seltzer Plus® products non-drowsy?

That depends upon the formula. The Alka-Seltzer Plus® formulas that contain an antihistamine to relieve your runny nose and sneezing may cause drowsiness.

Unlike the Alka-Seltzer Plus® Night-Time Cold formula, which relieves your symptoms to help you sleep without alcohol, the other Alka-Seltzer Plus® formulas are not intended to cause drowsiness. Drowsiness however, is a possible side effect of those products that contain an antihistamine.


Product Contains an antihistamine (x)
Effervescent Tablets
Alka-Seltzer Plus Cold Sparkling Original Effervescent
x
Alka-Seltzer Plus Classic/Regular Seltzer Effervescent
x
Alka-Seltzer Plus Cold Orange Zest Effervescent
x
Alka-Seltzer Plus Cold Cherry Burst Effervescent
x
Alka-Seltzer Plus Night Time Effervescent
x
Alka-Seltzer Plus Cold & Sinus Effervescent
Non-Drowsy
Alka-Seltzer Plus Cold & Cough Effervescent
x
Alka-Seltzer Plus Flu Effervescent
x
Alka-Seltzer Plus Day & Night Effervescent
x
Day:
Non-Drowsy
Night:
x
Liquid-Gels Contains an antihistamine (x)
Alka-Seltzer Plus Day Cold Liquid-gels
Non-Drowsy
Alka-Seltzer Plus Cough and Cold Liquid-gel
x
Alka-Seltzer Plus Night Cold Liquid-gel
x
Alka-Seltzer Plus Day & Night Liquid-gels
x
Day:
Non-Drowsy
Night:
x
Liquids Contains an antihistamine (x)
Alka-Seltzer Plus Day Cold Liquid
Non-Drowsy
Alka-Seltzer Plus Cold & Cough Liquid
x
Alka-Seltzer Plus Night Cold Liquid
x
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Can I use the Alka-Seltzer Plus® Night-Time Cold formula during the day?

This product is recommended to be taken at bedtime, as it may cause marked drowsiness. If you will be home and able to rest, then it may be taken during the day.

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Can I use the Alka-Seltzer Plus® formulas beyond the expiration date?

We do not recommend using our products after they expire. We recommend that you discard any expired Alka-Seltzer Plus® product. It will not be harmful if ingested, but it may not be as effective in relieving your symptoms.

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Can I dissolve Alka-Seltzer Plus® tablets in something other than water?

It dissolves better in tap water because it does not contain other compounds like other liquids do.(For example, because milk contains compounds such as water, protein, fat, etc., Alka-Seltzer Plus® would take longer to dissolve)

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What temperature of water should I use to dissolve Alka-Seltzer Plus® tablets?

The best temperature is room temperature. Cold water will slow down the dissolution and warm water can make the product foam excessively. If the effervescent formulas were placed in hot water, they would fizz so much that it would overflow out of the cup. With hot temperatures of water, the tablets will not sink to the bottom of the liquid but will rather float on top. Although the liquid may appear to be bubbling over the glass, the tablets are not dissolving in the most efficient way. The surface of the tablets needs to be submerged completely in water for rapid dissolution.

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What should I do if the tablets don't fizz?

This is a sign that the tablets may have started to break down. It is very likely that the foil packet has a slight imperfection or pin hole which has allowed moisture to come in contact with the tablets prematurely. This may also cause the tablets to discolor and crumble. While there is no safety concern, please be aware that the product will not be as effective.

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How long can I use Alka-Seltzer Plus®?

Discontinue use and consult a physician if pain, cough, or nasal congestion gets worse or lasts more than 7 days or if fever gets worse or lasts for more than 3 days

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Can I use Alka-Seltzer Plus® products if I'm pregnant or nursing?

As with any medication, if you are pregnant or breast-feeding a child, contact your doctor before using this product.

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Where can I buy Alka-Seltzer Plus® products?

See product locator link

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Does Alka-Seltzer Plus® contain Pseudoephedrine (PSE)?

At this time, all of our products contain the nasal decongestant Phenylephrine Hydrochloride. We are no longer manufacturing products with Pseudoephedrine. This ingredient was removed from formulations in 2006.

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Why does Alka-Seltzer Plus® Cold state that there is a maximum of 4 doses per day?

An internal decision was made by the Drug Safety and Regulatory Affairs departments at Bayer HealthCare to limit the maximum dosage of Alka-Seltzer Plus® Cold Effervescent Tablets in a 24 hour period to 8 tablets (4 doses). This is due to the amount of anhydrous citric acid in the formulation and the maximum amount allowed in a 24-hour period by FDA. To exceed 4 doses would be exceeding the regulations set forth by the FDA for anhydrous citric acid.

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I dislike products that are too sweet, what do you recommend?

Taste is very subjective from person to person and therefore we manufacture Alka Seltzer Plus® products in a variety of flavors. To try an effervescent formula with minimal flavorings, we recommend Alka-Seltzer Plus® Cold Regular Seltzer flavor.

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Use with other medications

Because interactions between drugs are always possible, a doctor or pharmacist should always be consulted before taking multiple medications.

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Does Alka-Seltzer Plus® contain gluten?

We do not add any gluten to our products. However, we cannot guarantee that they are 100% gluten free as this product is produced in a facility that manufactures or packages other items which may contain gluten.

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What is it that makes a product non-drowsy?

It is the absence of an antihistamine that makes some formulas non-drowsy. Not all products containing an antihistamine may cause marked drowsiness; it does vary greatly from person to person. The Alka-Seltzer Plus® products that do not contain an antihistamine are:

  • Effervescent Cold & Sinus Effervescent
  • Day Cold as part of the Day/Night combo
  • Day Cold Liquid-gels (solo and as part of Day/Night combo pack)
  • Day Cold Liquid
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